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Science
Built on peer-reviewed science.
CardioVive comes from the Aguirre Lab at Michigan State University. The platform is exclusively licensed to CytoHub and was built on $8.1M in federal research grants to the lab.
Publications
The platform, published.
Platform papers come from our founding lab, the Aguirre Lab at Michigan State University. CytoRNA-FM builds on scVision, a preprint from our research collaborators at Stanford University.
- 2026Preprint · collaborators
scVision: a vision foundation model for single-cell biology via spatial gene cartography
Pre-trained on 72 million public human cells; outperformed existing foundation models across six held-out studies. CytoRNA-FM builds on this model.
Yesiloglu et al., Stanford University · arXiv 2607.14163 · Read the preprint
- 2026Perspective · MSU
Immunoids: building immunocompetent organoids from human pluripotent stem cells
Defines “immunoids”, reviews immune-competent organoids across ten organ systems and proposes the first design standards for the field.
O’Hern et al., Aguirre Lab · Cell Stem Cell · doi:10.1016/j.stem.2026.08.016
- 2025Peer-reviewed · MSU
Human heart-macrophage assembloids model immune-cardiac interactions and arrhythmia
CardioPhage™ biology: stem-cell-derived macrophages engraft in heart tissue, shape its matrix and electrophysiology, and drive NLRP3-mediated atrial arrhythmia under inflammation.
O’Hern et al., Aguirre Lab · Cell Stem Cell · doi:10.1016/j.stem.2025.09.011
- 2024Preprint · MSU
Neural-crest heart assembloids
Models fetal heart development and SSRI cardiotoxicity.
Kostina et al., Aguirre Lab · bioRxiv, under review
- 2023Peer-reviewed · MSU
Patterned heart organoids and EMM2/1 maturation
Defined cell-type ratios and adult-grade electrophysiology.
Volmert et al., Aguirre Lab · Nature Communications
- 2021Peer-reviewed · MSU
Self-assembling human heart organoids
Organoids with atrial, ventricular and proepicardial regions that match 6–13-week human hearts.
Lewis-Israeli et al., Aguirre Lab · Nature Communications
Intellectual property
Eight patent families protect both halves of the loop.
4 patent families, exclusively licensed from MSU
From one stem cell to beating, maturing tissue. Bioreactor manufacturing know-how is held by CytoHub as a trade secret.
4 patent families, owned by CytoHub
The AI tools and CytoHub.AI, with imaging, motion and gene data in one shared representation.
Patent families cover methods, media, process and AI/ML. Filing and grant status is available to partners and investors under NDA.